GLOBAL EVOLUTION OF THE TUMOR MICROENVIRONMENT ASSOCIATED WITH PROGRESSION FROM PREINVASIVE INVASIVE TO INVASIVE HUMAN LUNG ADENOCARCINOMA

Global evolution of the tumor microenvironment associated with progression from preinvasive invasive to invasive human lung adenocarcinoma

Summary: To investigate changes in the tumor microenvironment (TME) during lung cancer progression, we interrogate tumors from two chest computed tomography (CT)-defined groups.Pure non-solid (pNS) CT density nodules contain preinvasive/minimally invasive cancers, and solid density nodules contain invasive cancers.Profiling data reveal a dynamic in

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TWO- AND THREE-DIMENSIONAL SIMULATIONS OF ASTEROID OCEAN IMPACTS

We have performed a series of two-dimensional and three-dimensional simulations of asteroid impacts into an ocean using the SAGE code from Los Alamos National Laboratory and Science Applications International Corporation.The SAGE code is a compressible Eulerian hydrodynamics code using continuous adaptive mesh refinement for following discontinuiti

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